Mechanism of RNA modification N6-methyladenosine in human cancer
نویسندگان
چکیده
منابع مشابه
N6-methyladenosine Modification in Bacterial mRNA
Among more than 140 naturally occurring RNA modifications have been identified, N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification in eukaryotic organisms. A group of demethylases, methyltransferase and m6A-specific binding proteins in mammals, plants as well as yeast are in support of the regulatory functions of this RNA modification. Recent years, with the fast de...
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Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control gene expression are often the target of cellular parasites, such as viruses. Gene expression is controlled through multiple mechanisms that are coordinated to ensure the proper and timely expression of each gene. Many of these mechanisms tar...
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N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional...
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The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes methyltransferases and demethylases that add or remove this modification, as well as m6A-binding YTHDF proteins that promote the translation or degradation of m6A-modified mRNA. We demonstrate that m6A modulates infection by hepatitis C virus (HCV). Depl...
متن کاملN6-methyladenosine-dependent regulation of messenger RNA stability
N-methyladenosine (mA) is themost prevalent internal (non-cap) modificationpresent in themessengerRNAofall higher eukaryotes. Although essential to cell viability and development, the exact role ofmAmodification remains tobedetermined.The recent discovery of twomAdemethylases inmammalian cells highlighted the importance of mA in basic biological functions and disease. Here we show that mA is se...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2020
ISSN: 1476-4598
DOI: 10.1186/s12943-020-01216-3